<i>In Vitro</i> and <i>in Vivo</i> Studies of the Antiparasitic Effect of Aspirin Against <i>Dactylogyrus Extensus</i> (Monogenea) Invasion in Carp (<i>Cyprinus carpio</i>)

Abstract Aspirin is one of the most widely used medications globally as an analgesic and antipyretic drug. use antiparasitic against fish parasites has never been tested. The parasite Dactylogyrus considered a serious threat to freshwater aquaculture in relation considerable losses. present study aimed evaluate effect aspirin extensus on Cyprinus carpio alteration gill histopathology. In vitro , exhibited activity with median effective concentration (EC50) values at six minutes 8.137 g/L −1 1.629 were assessed for first time. vivo efficacy D. was found be 46.49%. Severe lesion profile observed histopathological evaluations gills.